Example of key assays designed to test both small molecules and biologics in the search of targeted immunotherapies:
- CD4 T cell: Th1/2/17 polarisation, Th17 function, Tr1/iTreg polarisation, nTreg suppression, Tfh, naïve, CM and EM phenotype/function, polyclonal and antigen-specific T cell proliferation and cytokine release
- CD8 T cell: activation, proliferation and function. Polyclonal and antigen-specific T cell responses
- B cell: Antibody production (Total IgG), Memory B cell Antibody Isotypes, Naïve B cells Isotype switching, B cell proliferation/activation/cytokine secretion, Antigen presentation. Tonsiller Organoids
- Dendritic cell: Antigen presentation
- Innate Lymphoid Cell: ILC1/2/3 phenotype and cytokine production
- Cellular Therapy: Treg (on target assay, cellular persistence, exhaustion, immunogenicity, tumorgenicity)