Neuro Inflammation in vitro assays
Therapeutic Area
Use human iPSC-derived multicellular assays to accelerate your neuroinflammatory drugs
There is a growing literature on the contribution of the immune response to neurodegenerative diseases. We have developed targeted assays to evaluate novel therapeutics that modulate microglia-derived cytokines and chemokines, and dysregulated phagocytic activity enabling assessment of their impact on downstream neuronal damage.
Example assays: Mixed lymphocyte reactions (MLR) → immune migration → iPSC- bi-cultures → Inflammasome- NLRP3/IL-1β → iPSC microglia phagocytosis → iPSC neuronal function
Key Assays
Example of key assays designed to test small molecules, biologics, cellular therapies, vaccines and nutraceuticals
Neuroinflammation FAQ
Do you use iPSC-derived microglia in your assays?
Yes, our neuroinflammation assays use iPSC-derived microglia to evaluate inflammatory cytokines and phagocytosis of apoptotic cells or synthetic particles under different inflammatory conditions.
Do you provide assays to assess the impact of inflammation on neurons?
Yes, we can use neurite outgrowth assays to evaluate how inflammatory cytokines, chemokines, or drug candidates influence neuronal morphology and health.
Do you offer co-culture models for neuroinflammation?
We provide iPSC derived microglia and iPSC derived neuronal bi-culture assays to better replicate in vivo neuroinflammatory conditions. Please follow us on Linked In or visit our Insights section for updates on our neuro tri-culture assays.
What Our Partners say about Nexus
Drug Discovery Tool
Find the right immune assay for your therapeutic area, modality and target using our interactive Drug Discovery Tool.