Autoimmunity in vitro assays
Therapeutic Area
We provide human relevant in vitro assay models to evaluate therapeutic immune modulation. These include our tonsil re-aggregate model, which replicates the initial priming of autoreactive immune responses in a secondary lymphoid organ, and our co-culture models that capture the cross talk between immune cells and tissue resident cells, for example those found in the skin or joints.
Key Assays
Example of key assays designed to test small molecules, biologics, cellular therapies, vaccines and nutraceuticals
Frequently Asked Questions
Can you model specific autoimmune diseases in your assays?
Yes, we have in vitro immune cell assays that model autoimmune diseases such as rheumatoid arthritis, lupus, psoriasis and multiple sclerosis. Using these autoimmune disease models we can test novel therapeutics that target autoreactive immune responses.
Do you use diseased immune cells from autoimmune patients in your assays?
Yes, we use immune cells from healthy donors and autoimmune patients to evaluate therapeutic mechanism of action (MOA) and translation into the disease setting.
Do you provide assays to evaluate B cell function in autoimmunity?
Yes, we provide B cell function assays for autoimmunity using our tonsil organoid model or peripheral blood. The assays evaluate T cell: B cell cross talk, antigen-specific B cell proliferation, activation, antibody production (total IgG and isotype switching) and memory B cell responses. We also assess therapeutic effects on key B cell subsets such as naive, pre-GC, GC, memory, plasmablast/cytes.
What Our Partners say about Nexus
Drug Discovery Tool
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