Example of key assays designed to test therapeutics that modulate drivers of acute and chronic inflammation:
- Neutrophil: Respiratory Burst (ROS, Phagoburst), NETs
- Epithelial: EMT, keratinocyte cytokine release, Epithelial interface-barrier integrity, tight junction, TEER, cytokine release. Epithelial/immune cell co-culture
- Fibroblast: FMT
- Monocyte: Inflammasome/LPS cytokine release
- Macrophage: M1/M2 polarisation and function
- Innate Lymphoid Cell: ILC1/2/3 phenotype and cytokine production
- Basophil/ Eosinophil/Mast cell
- CD4 T cell: Cytokine Release Assay-predictive toxicity