Inflammation and Hypersensitivity in vitro assays
Therapeutic Area
Discover what sets your drug apart with insights from our immunology experts
Uncontrolled inflammation that causes tissue damage has driven the need for targeted immuno-modulators. In many cases inflammation is not driven by autoimmunity, but by: innate immune activation (inflammasomes), pathogen and allergen exposure, tissue injury and remodeling, environmental or metabolic stress. We provide multicellular models that recapitulate disease such as Atopic Dermatitis, Asthma, Inflammatory Bowel Disease.
Example assays: Mixed lymphocyte reactions (MLR) → Th2 (IL-4/13 axis) → B cell IgE antibody production → Inflammasome- NLRP3/IL-1β assays → M1, M2a-d polarisation → Neutrophil ROS, immune complex NETosis
Key Assays
Example of key assays designed to test small molecules, biologics, cellular therapies, vaccines and nutraceuticals
Inflammation FAQ
Can you test both acute and chronic inflammatory responses?
Yes, we offer in vitro inflammation assays to test both acute (neutrophil activation, monocyte cytokine release) and chronic inflammation (macrophage, fibroblast and epithelial interactions).
Do you offer assays to assess inflammasome activation?
Yes, we offer NLRP3 inflammasome assays to study chronic inflammatory diseases such as such as arthritis, Alzheimer’s disease and inflammatory bowel disease. Inflammasome activation is driven using a variety of TLR and DAMPs signals; IL-1b and IL-18 is controlled using NLRP3 inhibitors.
Can you evaluate whether a drug candidate will drive cytokine release syndrome?
Yes, we offer cytokine release assays (CRA) to evaluate the potential risk of novel biologics or cellular therapies to drive cytokine release syndrome. These assays are performed using both healthy and disease-derived immune cells to assess safety in early drug development and to support IND-submissions.
What Our Partners say about Nexus
Drug Discovery Tool
Find the right immune assay for your therapeutic area, modality and target using our interactive Drug Discovery Tool.