Nexus

Neuro Inflammation in vitro assays

Therapeutic Area

We provide pre-clinical services that test therapeutics aiming to limit and control inflammation within the central nervous system.
There is a growing literature on the contribution of the immune response to neurodegenerative diseases. We have designed assays that test novel therapeutics aimed at preventing or blocking the inflammatory cytokines/chemokines generated by microglial cellsand aspects of microglial function such as phagocytosis.

Key immune cells targeted to treat neuro inflammation
neuroinflammation

Frequently Asked Questions

Do you use iPSC-derived microglia in your assays? 

Yes, our neuroinflammation assays use iPSC-derived microglia to evaluate inflammatory cytokines and phagocytosis of apoptotic cells or synthetic particles under different inflammatory conditions. 

Do you provide assays to assess the impact of inflammation on neurons? 

Yes, we can use neurite outgrowth assays to evaluate how inflammatory cytokines, chemokines, or drug candidates influence neuronal morphology and health. 

Do you offer co-culture models for neuroinflammation? 

We are developing microglia-neuron co-culture models to better replicate in vivo neuroinflammatory conditions. Please follow us on Linked In or visit our Insights section for any updates on our progress. 

What Our Partners say about Nexus

The team at Nexus are fantastic! Great adaptability at working with highly bespoke requests and difficult experiments to keep the project on track and deliver within aggressive timelines. A highly flexible, friendly and efficient team to work with!

Wayne Paes

Principal Scientist. Greywolf Therapeutics

We have been delighted with our interactions with  Nexus BioQuest. I first reached out to them after a recommendation from a former colleague. I appreciated their ability to suggest immunoassay options to address the question of interest (as a neurobiologist, the immune system definitely works in mysterious ways!). This was further bolstered by exemplary attention to detail when putting together a  work package proposal which was then efficiently executed. The skill set, responsiveness, knowledge base, effort, effectiveness, transparent and regular communication were all outstanding and I have no hesitation whatsoever in recommending Nexus BioQuest as a partner of choice.

Caroline Benn

Chief Scientific Officer and co-founder

Our work with Nexus BioQuest initially started with developing a novel T cell assay and grew from there into a much larger screening project. Working with Nexus has been a fantastic experience, marked by their deep expertise in immunology and friendly staff. At the onset of the project, Nexus really took the time to understanding of our project needs, setting us up for success throughout. Nexus distinguishes themselves by their enthusiasm, knowledge, and commitment to excellence, with contributed significantly to the development of a tailored assay that exceeded our  expectations.

Ryan Shaler

Director, Sonata Therapeutics

I would like to thank the team at Nexus BioQuest for providing an excellent and professional service supporting our R&D development activities. The Nexus team were great to work with from contract signature to delivery of final reporting. I would certainly recommend their contract services to companies seeking immunology expertise and agile research solutions.

Andrew Mearns Spragg

Chief Scientific Officer, Jellagen

Our experience of working with Nexus was excellent, we felt they held the expertise required for the task at hand, working well together as a high performing  team and presenting well researched solutions to assay development and the problems encountered. We wanted a fresh outlook for assay development for our  project and the team were able to rapidly research the literature and come up with proposals. The team were flexible and dynamic in their approach providing  honest feedback and critique to methods and results.  We would certainly work with Nexus again and would not hesitate to  recommend them as a CRO for immunological assay development.

Seema Patel

Immuno-oncology Alliance Science Program Lead, LifeArc

Working with Nexus BioQuest has been an absolutely wonderful experience. As a smaller biotechnology company that relies heavily on CRO support to execute our lab-based activities, we could not have found a better biological team to partner with. We needed a team to generate our biological package for a new pipeline candidate and we were fortunate to find Nexus and have them deliver a wonderful data package that will help the Bluejay team move our program forward. Working with this group felt like having an internal Bluejay R&D team from ease of execution, to great scientific discussions and troubleshooting, and having the feeling that the Nexus team was truly invested in the success of our program. I cannot recommend the Nexus team enough and will greatly look forward to collaborating with them again on our next programs and projects!

Hilario Ramos

Sr. Director, Head of Immunology

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