3D Tumour killing models: tool for screening immune therapeutics

Macrophages are highly plastic and can differentiate into a range of activated phenotypes driven by external signals under various disease conditions. Therapeutic driven modulation of macrophage phenotype has the potential to modulate many different disease types where macrophage play a key role in either driving or regulating disease. We present here a range of macrophage […]

Neutrophils are amongst the first immune cells to respond to injury or infection. Armed with a variety of effector mechanisms, they release neutrophil extracellular traps (NETs), comprising of chromatin and antimicrobial proteins which are released via a unique, pro-inflammatory form of cell death called NETosis. Dysregulated NET release can damage the host, contributing to autoimmune […]