Immunology CRO

Pre-clinical

WHAT WE DO AND WHY

Drug Discovery is rarely a one size fits all, each programme comes with its own scientific challenges, timelines and budget considerations. That is why we provide thoughtful solutions designed to meet the specific needs of your programme and guide it towards IND readiness.

Our Therapeutic Areas of Focus

Our focused expertise in immunological research allows us to deep-dive into various aspects of the field, ensuring comprehensive support for your drug development programmes.

Immune-oncology: At Nexus BioQuest, we focus on providing human in vitro translational assays for the testing of novel Immuno-Oncology and Oncology therapeutics. Our services span from target validation, mechanism of action, efficacy, predictive immunotoxicology supporting your therapeutic through pre-clinical validation to IND readiness. Our Scientists help design your pre-clinical package and have extensive expertise in biologics (ADC, monoclonal, bi-specifics, T-cell engagers), cellular therapies, and small molecules. We leverage cutting-edge technologies (2D and 3D assays) and methodologies (healthy and diseased biospecimens) to understand how your drug works and identify key differentiators from therapeutics already in the clinic.

contract research organisation (CRO) for cell. Contract Assay Services

Autoimmunity

Our team of specialised immunologists is committed to advancing treatments that address some of the most challenging and critical conditions in immunology.

Autoimmunity: Autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, Type 1 diabetes and SLE are suffered by many. Here at Nexus BioQuest, we understand the underlying causes of such conditions and provide human in vitro translational assays to test your novel therapeutics’ mode-of-action, efficacy and risk profile. Pre-clinical Autoimmune drug discovery is growing at tremendous speed, we provide translational ex vivo and in vitro assays using secondary lymphoid organ (SLO) or human immune cells from healthy or diseased individuals to accelerate pre-clinical drug development. Our scientists provide a breath of experience to streamline your drug programmes to deliver pre-clinical data packages for IND readiness.

Inflammation

Inflammation and Neuro-inflammation: The study of inflammation is a continuous focus for many scientists, aiming to address the issue of uncontrolled systemic inflammation that can lead to conditions such as Atopic Dermatitis, Psoriasis, Crohn’s disease, and Asthma. Chronic inflammation can also occur in the CNS, contributing neurodegenerative diseases such as Alzheimers and Parkinsons Disease; we provide iPSC mono-, bi-tri cultures using disease relevant protein aggregates such as alpha-synuclein or beta-amyloid which are key disease drivers of neuroinflammation. Here at Nexus BioQuest, we are experts in modelling neuro/inflammatory processes in vitro, offering specialised pre-clinical testing services for your novel immuno-therapeutics.

Drug Discovery Tool

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Why Partner with Nexus Bioquest?

State-of-The-Art Technology Platforms

Using state-of-the-art technology, our team of expert immunologists can execute custom pre-clinical programmes that ensure your drug’s safety profile. These are some of the technology platforms we utilise here at Nexus BioQuest to conduct studies that make a real difference.

ImageXpress Confocal HT.ai High-Content Imaging System
Cytena CellCyte Real Time Imaging
Novocyte Pentium Flow Cytometer
Olink Proteomics

Bespoke Approach to CRO Services

Partnering with Nexus Bioquest is partnering with ongoing immunological innovation. We provide clients with immunological expertise following this CRO framework we believe that fosters ongoing collaboration through each phase:

Consultation – Engagement with our specialised team of immunologists with a broad expertise in planning, operating and assessing pre-clinical studies.
Study design and pricing – Collaborative and tailored approach to a drug discovery programme, with a detailed breakdown of pricing for each service.
Contract and proposal formulation – Comprehensive and professional documentation of trial design, ensuring maximum clarity on both ends.
Laboratory execution – Implementation of pre-clinical in vitro studies supplemented with expert oversight over preliminary drug development programme.
Data package and recommendations – Proficient and efficient communication of harvested data, with clear and precise data-driven feedback for the next steps of your drug development programme.

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Nexus BioQuest immunology CRO business development team on a Teams call

Our Principal Immunologists

Sally Woodman

Christopher Rice

Silvia Rosini

Helen Tunbridge

What our clients say

We have been delighted with our interactions with Nexus BioQuest. I first reached out to them after a recommendation from a former colleague. I appreciated their ability to suggest immunoassay options to address the question of interest (as a neurobiologist, the immune system definitely works in mysterious ways!). This was further bolstered by exemplary attention to detail when putting together a work package proposal which was then efficiently executed. The skill set, responsiveness, knowledge base, effort, effectiveness, transparent and regular communication were all outstanding and I have no hesitation whatsoever in recommending Nexus BioQuest as a partner of choice.

Caroline Benn

Chief Scientific Officer and co-founder

Our work with Nexus BioQuest initially started with developing a novel T cell assay and grew from there into a much larger screening project. Working with Nexus has been a fantastic experience, marked by their deep expertise in immunology and friendly staff. At the onset of the project, Nexus really took the time to understanding of our project needs, setting us up for success throughout. Nexus distinguishes themselves by their enthusiasm, knowledge, and commitment to excellence, with contributed significantly to the development of a tailored assay that exceeded our expectations.

Ryan Shaler

Director, Sonata Therapeutics

I would like to thank the team at Nexus BioQuest for providing an excellent and professional service supporting our R&D development activities. The Nexus team were great to work with from contract signature to delivery of final reporting. I would certainly recommend their contract services to companies seeking immunology expertise and agile research solutions.

Andrew Mearns Spragg

Chief Scientific Officer, Jellagen

Our experience of working with Nexus was excellent, we felt they held the expertise required for the task at hand, working well together as a high performing team and presenting well researched solutions to assay development and the problems encountered. We wanted a fresh outlook for assay development for our project and the team were able to rapidly research the literature and come up with proposals. The team were flexible and dynamic in their approach providing honest feedback and critique to methods and results. We would certainly work with Nexus again and would not hesitate to recommend them as a CRO for immunological assay development.

Seema Patel

Immuno-oncology Alliance Science Program Lead, LifeArc

Working with Nexus BioQuest has been an absolutely wonderful experience. As a smaller biotechnology company that relies heavily on CRO support to execute our lab-based activities, we could not have found a better biological team to partner with. We needed a team to generate our biological package for a new pipeline candidate and we were fortunate to find Nexus and have them deliver a wonderful data package that will help the Bluejay team move our program forward. Working with this group felt like having an internal Bluejay R&D team from ease of execution, to great scientific discussions and troubleshooting, and having the feeling that the Nexus team was truly invested in the success of our program. I cannot recommend the Nexus team enough and will greatly look forward to collaborating with them again on our next programs and projects!

Hilario Ramos

Sr. Director, Head of Immunology

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